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Upon oxidation, bilirubin is converted into various forms of bilirubin oxidation metabolites (BOMs), comprising at least seven hydrophilic metabolites that are promptly excreted into urine because of their hydrophilic nature (132)

Researchers should consider the trial design, reported frequency, severity, discontinuation patterns and any dose-related observations

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Initial Application : Apply a pea-sized amount of tretinoin cream to clean, dry skin every two to three nights initially